Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
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Comparative Study
Mallampati class is not useful in the clinical assessment of sleep clinic patients.
To assess the utility of Mallampati class, a simple grade of oropharyngeal appearance used to assess difficulty of intubation, to predict severe obstructive sleep apnea and absence of OSA (rule in severe OSA and rule out OSA). ⋯ Mallampati class is associated with AHI but does not significantly modify likelihood of severe OSA or absence of OSA. As such, it is of limited use to "rule in" severe OSA or "rule out OSA" in the sleep clinic population.
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Randomized Controlled Trial Multicenter Study Comparative Study
The nightly use of sodium oxybate is associated with a reduction in nocturnal sleep disruption: a double-blind, placebo-controlled study in patients with narcolepsy.
To further explore the effects of sodium oxybate (SXB) administration on nocturnal sleep in narcolepsy patients during a double-blind, placebo-controlled, parallel group study conducted with 228 adult patients with narcolepsy/cataplexy in the United States, Canada, and Europe. ⋯ The nightly administration of SXB to narcolepsy patients significantly impacts measures of slow wave sleep, wake after sleep onset, awakenings, total sleep time, and stage 1 sleep in a dose-related manner. The frequency and severity of narcolepsy symptoms decreased with treatment.
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Randomized Controlled Trial Comparative Study
Effectiveness of ramelteon for insomnia symptoms in older adults with obstructive sleep apnea: a randomized placebo-controlled pilot study.
To evaluate the effectiveness of ramelteon, a melatonin receptor agonist, for the treatment of insomnia in older adults starting auto-titrating positive airway pressure (APAP) therapy for sleep apnea. ⋯ Ramelteon was effective in improving objective, but not subjective, sleep onset latency even in older adults who were starting APAP therapy for sleep apnea. Further research is warranted in examining the role of ramelteon in the care of older adults with insomnia symptoms and sleep apnea.