Alzheimer's & dementia : the journal of the Alzheimer's Association
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Meta Analysis Comparative Study
Phenotypic regional functional imaging patterns during memory encoding in mild cognitive impairment and Alzheimer's disease.
Reliable blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) phenotypic biomarkers of Alzheimer's disease (AD) or mild cognitive impairment (MCI) are likely to emerge only from a systematic, quantitative, and aggregate examination of the functional neuroimaging research literature. ⋯ ALE consistencies broadly support the presence of frontal compensatory activity, medial temporal lobe activity alteration, and posterior midline "default mode" hyperactivation during episodic memory encoding attempts in the diseased or prospective predisease condition. Taken together, these robust commonalities may form the foundation for a task-based fMRI phenotype of memory encoding in AD.
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Homocysteine may be a modifiable risk factor for cognitive decline and brain atrophy, particularly in older persons. We examined whether homocysteine increased the risk for cognitive decline and brain atrophy, and evaluated the modifying effect of age. ⋯ Elevated tHcy was related to progression of ventricular enlargement and increased the risk for a decline in executive functioning in older persons.