Journal of Zhejiang University. Science. B
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J Zhejiang Univ Sci B · May 2013
Meta Analysis Comparative StudyLevosimendan versus dobutamine in critically ill patients: a meta-analysis of randomized controlled trials.
To evaluate the clinical efficacy of levosimendan versus dobutamine in critically ill patients requiring inotropic support. ⋯ In contrast with dobutamine, levosimendan is associated with a significant improvement in mortality in critically ill patients requiring inotropic support. Patients having cardiac surgery, with ischemic heart failure, and receiving concomitant β-blocker therapy may benefit from levosimendan. More RCTs are required to address the questions about no positive outcomes in the subpopulation in a cardiology setting, and to confirm the advantages in long-term prognosis.