Journal of Zhejiang University. Science. B
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J Zhejiang Univ Sci B · Mar 2014
Review Meta AnalysisAssociation of matrix metalloproteinase-9 C1562T polymorphism and coronary artery disease: a meta-analysis.
Many investigations have studied the associations between matrix metalloproteinase-9 (MMP-9) C1562T polymorphisms and coronary artery disease (CAD). However, the conclusions of these studies were inconsistent. Therefore, this study was aimed at clarifying the association between MMP-9 C1562T polymorphisms and CAD in a large-scale meta-analysis. ⋯ Our meta-analysis suggested an obvious ethnic difference in the association between MMP-9 C1562T polymorphisms and CAD. MMP-9 C1562T polymorphism was significantly related to CAD in East Asians. However, no significant associations were observed in either West Asians or Western populations.