Future cardiology
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Evaluation of: Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. Taylor AL, Zieche S, Yancy C et al.: N. Engl. ⋯ These data represent a significant advance in the medical management of African-American patients with advanced systolic heart failure. Additionally, the design of the AHeFT study represents a novel approach to the design of clinical trials in heart failure, based on an understanding of the mechanism of action of drugs and the underlying pathophysiology of the disease state in specific patients groups. Future research will be required to assess whether benefits of this drug combination seen in AHeFT can be extended to the wider population of patients with advanced heart failure.