Revista espanola de anestesiologia y reanimacion
-
Rev Esp Anestesiol Reanim (Engl Ed) · Jun 2019
Randomized Controlled TrialClinical trial on the effect of tranexamic acid on bleeding and fibrinolysis in primary hip and knee replacement.
Tourniquet-induced ischaemia could increase fibrinolysis and enhance tranexamic acid (TXA) efficacy in total knee arthroplasty (TKA) compared to total hip arthroplasty (THA). The aims of this study are to compare the effect of TXA on bleeding and fibrinolysis in both types of surgery, and to record thromboembolic complications. ⋯ Prophylactic use of tranexamic acid is equally effective in reducing bleeding in TKA and THA. Both surgeries have a similar effect on fibrinolysis.