Asia-Pacific journal of clinical oncology
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Asia Pac J Clin Oncol · Dec 2010
Randomized Controlled TrialUse of calcium and magnesium infusions in prevention of oxaliplatin induced sensory neuropathy.
Oxaliplatin-related neurotoxicity is frequently dose-limiting. Following retrospective studies suggesting neuroprotective effects of calcium and magnesium (Ca and Mg), we conducted a prospective study using nerve conduction studies (NCS) to evaluate the effectiveness of such infusions in oxaliplatin-related neuropathy. ⋯ Premature closure of this study limits the interpretation of results. While there was a trend towards reduced subjective acute sensory neuropathy with Ca and Mg, this was not significant. Ca and Mg failed to reduce the rate of cumulative sensory neuropathy and instead increased the rate of abnormal NCS, suggesting a significant difference in perceived sensory and objective neuropathy.
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Asia Pac J Clin Oncol · Dec 2010
Case ReportsMultiple myeloma presenting as eosinophilic pleural effusion.
An elderly man, with no comorbidity, presented with rapidly accumulating left pleural effusion. He also had generalized adenopathy. ⋯ On further investigation he was found to have kappa-light chain multiple myeloma. The final diagnosis was eosinophilic pleural effusion in a patient with multiple myeloma.