Clinical toxicology : the official journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
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We present a case of a 49-year-old male dentist with myeloneuropathy. He used nitrous oxide frequently in his practice, and denied recreational use. ⋯ The patient was treated with vitamin B12 and l-methionine. A repeat MRI of his cervical spinal cord 3 months after hospital discharge showed complete regression of the hyperintense signal on T2 within the posterior columns.
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Clin Toxicol (Phila) · Dec 2008
Case ReportsObtundation and seizure following ondansetron overdose in an infant.
Ondansetron, an increasingly prescribed 5-HT(3) antagonist used in the management of nausea and vomiting of various etiologies, has a well-established safety profile in therapeutic use. However, little is known about its effects in the setting of an overdose. We describe the first case of severe toxicity in an infant who unintentionally ingested a large quantity of ondansetron. ⋯ Health care providers should recognize the risk for acute toxicity following ondansetron overdose, particularly in infants and toddlers.
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Clin Toxicol (Phila) · Dec 2008
2007 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 25th Annual Report.
This report is the 25th Annual Report of the American Association of Poison Control Centers (AAPCC; http://www.aapcc.org) National Poison Data System (NPDS). During 2007, 60 of the nation's 61 U.S. Poison Centers upload case data automatically. The median upload time is 14 [5.3, 55] (median [25%, 75%]) min creating a real-time national exposure database and surveillance system. ⋯ Poisoning continues to be a significant cause of morbidity and mortality in the United States NPDS represents a valuable national resource to collect and monitor U.S. poisoning exposure cases. It offers one of the few real-time surveillance systems in existence, provides useful data, and is a model for public health surveillance.
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Clin Toxicol (Phila) · Dec 2008
Case ReportsReversal of ergotamine-induced vasospasm following methylprednisolone.
Ergotamine, an ergot alkaloid with partial agonist effects on alpha1 receptors and serotonin receptors, is widely used in the treatment of migraine. Ergotamine may cause severe vasospasm. ⋯ Ischemia in an extremity secondary to ergotamine-induced vasospasm unresponsive to sodium nitroprusside may be treated successfully with methylprednisolone.
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Clin Toxicol (Phila) · Dec 2008
Case ReportsOxcarbazepine-induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS).
This is an image and brief case report of a 13-year-old boy who presented with severe rash and systemic symptoms after starting oxcarbazepine. The patient was diagnosed and treated for Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), a syndrome of fever, rash, and internal organ involvement secondary to medication administration. The image illustrates the rash seen with this drug reaction. The report is followed by a brief review of anticonvulsant hypersensitivity syndrome and DRESS.