Clinical toxicology : the official journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
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Clin Toxicol (Phila) · Jun 2011
Case ReportsSevere propranolol and ethanol overdose with wide complex tachycardia treated with intravenous lipid emulsion: a case report.
Propranolol is a highly lipid-soluble beta-blocker. We describe a case of severe propranolol overdose, with atypical dysrhythmia--wide complex tachycardia--which was successfully treated with lipid emulsion. ⋯ We believe that lipid emulsion had a beneficial effect in the treatment of propranolol toxicity.
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Clin Toxicol (Phila) · Jun 2011
Medication errors associated with the use of ethanol and fomepizole as antidotes for methanol and ethylene glycol poisoning.
Little is known about medication errors which occur with the antidotes ethanol and fomepizole, used for treatment of methanol and ethylene glycol poisoning. Study objectives were to describe and compare the frequency, type, outcome and underlying causes of medication errors associated with ethanol and fomepizole. ⋯ Fomepizole was less prone to medication error than ethanol. Error-related harm was most commonly due to excessive antidote dose or delayed antidote initiation.
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Clin Toxicol (Phila) · Jun 2011
The combination of cobinamide and sulfanegen is highly effective in mouse models of cyanide poisoning.
Cyanide is a component of smoke in residential and industrial fires, and accidental exposure to cyanide occurs in a variety of industries. Moreover, cyanide has the potential to be used by terrorists, particularly in a closed space such as an airport or train station. Current therapies for cyanide poisoning must be given by intravenous administration, limiting their use in treating mass casualties. ⋯ The combination of cobinamide and sulfanegen shows great promise as a new approach to treating cyanide poisoning.