Clinical toxicology : the official journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
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Clin Toxicol (Phila) · Jun 2012
Comparative StudyComparison of citalopram and other selective serotonin reuptake inhibitor ingestions in children.
In adults, citalopram is more likely to cause seizures and ECG changes than other selective serotonin reuptake inhibitors (SSRIs). Data in children are lacking, yet the 2007 American Association of Poison Control Centers out-of-hospital citalopram consensus guideline mirrors the guideline for other SSRIs. ⋯ Children develop minimal toxicity with SSRI ingestions. Seizures and ECG changes, while uncommon, occur more frequently with citalopram. Doses associated with significant outcomes suggest that the triage guideline for citalopram does not need to be modified.
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Clin Toxicol (Phila) · Jun 2012
The EXTRIP (EXtracorporeal TReatments In Poisoning) workgroup: guideline methodology.
Extracorporeal treatments (ECTRs), such as hemodialysis and hemoperfusion, are used in poisoning despite a lack of controlled human trials demonstrating efficacy. To provide uniform recommendations, the EXTRIP group was formed as an international collaboration among recognized experts from nephrology, clinical toxicology, critical care, or pharmacology and supported by over 30 professional societies. For every poison, the clinical benefit of ECTR is weighed against associated complications, alternative therapies, and costs. ⋯ A modified Delphi method with two voting rounds was used, between which deliberation was required. Each statement was voted on a Likert scale (1-9) to establish the strength of recommendation. This approach will permit the production of the first important practice guidelines on this topic.
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Clin Toxicol (Phila) · Jun 2012
Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: a retrospective cohort study.
To examine whether postpartum maternal prescription of codeine was associated with an increased risk of harm to newborns. ⋯ In this large population-based study, maternal prescription of codeine following delivery was not associated with death or hospitalization in the early neonatal period.
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Clin Toxicol (Phila) · Jun 2012
Adherence to calcium channel blocker poisoning treatment recommendations in two Canadian cities.
No study has documented whether physicians call poison control centres (PCC) for calcium channel blocker (CCB) poisoning or if interventions suggested by the PCC are being applied. ⋯ In conclusion, the majority of the physicians did not follow PCC recommendations for the treatment of CCB poisoning. Further studies are ongoing as to evaluate the barriers to protocol adherence and to develop evidence based guidelines accompanied by an effective implementation strategy.