Cellular & molecular immunology
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Cell. Mol. Immunol. · Jun 2009
Expression of IL-10 and TNF-alpha in rats with cerebral infarction after transplantation with mesenchymal stem cells.
We investigated the effects of bone marrow-derived mesenchymal stem cells (MSCs) transplantation on the recovery of neurological functions in rat's MCAO (middle cerebral artery occlusion) model and its mechanism. MSCs were isolated from bone marrow of male Sprague Dawley (SD) rats. Female adult SD rats were randomly assigned into 4 groups: sham-operated group, MCAO group, vehicle group and MCAO + MSCs-treated group. ⋯ However, the expression of TNF-alpha at day 4 after MCAO in the MSCs group significantly decreased compared with that of the MCAO group and the vehicle group. As a result, transplantation with MSCs significantly decreased infarct volume at day 1 and 4. This study strongly suggested transplantation with MSCs could reduce neuronal injury post focal cerebral ischemia in rats partly by regulating the expressions of IL-10 and TNF-alpha in the brain.