Journal of cancer research and therapeutics
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To analyze outcomes of reirradiation with stereotactic radiosurgery (SRS) for patients with brain metastases from small cell lung cancer (SCLC). ⋯ SRS for reirradiation of brain metastases from SCLC is safe and achieves local tumor control in the majority of patients. Despite SRS, these patients are at high risk of distant brain failure.
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The Monte Carlo dose calculation algorithm yields accurate dose distributions in heterogeneous media and interfaces. The Monte Carlo calculation algorithm provided in the Multiplan Cyberknife treatment planning system (Accuray, Sunnyvale, CA, USA) has five different dose-smoothing algorithms in it. As the principle of smoothing of these algorithms is different, they can produce a disparity in the final dose distribution. The aim of the present study is to analyze the influence of these Monte Carlo smoothing algorithms in the final dose distribution of cyberknife treatment plans. ⋯ The deviations between the smoothing algorithms are higher in the high-dose regions, including the prescribing isodose, than the low-dose regions of the target, as well as in the organs at risk (OAR).