Congenital heart disease
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Congenital heart disease · Nov 2010
Randomized Controlled Trial Multicenter Study Comparative StudyPlatelet activity associated with concomitant use of clopidogrel and proton pump inhibitors in children with cardiovascular disease.
In adults with acute coronary syndrome, decreased platelet inhibition associated with concomitant use of clopidogrel and proton pump inhibitors (PPI) has been reported. ⋯ Concomitant use of PPI + clopidogrel may be associated with decreased platelet inhibition in children with cardiac disease. Further study in a larger population and assessment of associated clinical outcomes is warranted.