Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
-
J Neuroimmune Pharmacol · Sep 2015
Alterations in Spinal Cord Metabolism during Treatment of Neuropathic Pain.
Therapeutic options for neuropathic pain have improved over the last 20 years yet still only provide partial relief with numerous side effects. Recently, metabolomics revealed that the concentration of the endogenous metabolite N,N-dimethylsphingosine (DMS) is increased in the spinal cord in a model of neuropathic pain. ⋯ We found that the concentration of DMS in the spinal cord was not significantly altered upon pregabalin treatment of rats suffering from neuropathic pain. We further explored whether modulating lipid metabolism may impact neuropathic pain by testing NOE as a potential novel therapeutic.