Journal of cardiovascular medicine
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J Cardiovasc Med (Hagerstown) · Nov 2006
Comparative Study Clinical TrialMetabolic syndrome in obstructive sleep apnea and related cardiovascular risk.
There is little evidence available about the relationship between metabolic syndrome as a comprehensive clinical entity and obstructive sleep apnea (OSA) with respect to the cardiovascular risk of patients with coexisting metabolic syndrome and OSA. ⋯ Metabolic syndrome was a frequent comorbidity in OSA patients, reflecting higher degrees of sleep-disordered breathing, and did not increase the risk of cardiovascular events after adoption of CPAP therapy.
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J Cardiovasc Med (Hagerstown) · Nov 2006
Case ReportsA case of acute myocardial infarction during 5-fluorouracil infusion.
Cardiac toxicity is an uncommon side-effect of 5-fluorouracil (5-FU) treatment, consisting mainly of chest pain episodes with or without electrocardiographic changes and dysrhythmias. Here, we describe the case of a 56-year-old male patient with a diagnosis of advanced colorectal cancer who developed an acute myocardial infarction during 5-FU infusion. ⋯ Given the great number of cancer patients receiving 5-FU containing chemotherapeutic regimens, this rare but severe cardiac side-effect may be observed in both cardiologic and oncologic clinical practice. We suggest a tight clinical monitoring of all patients receiving 5-FU infusions, even in those without a prior history of heart disease.
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J Cardiovasc Med (Hagerstown) · Nov 2006
Clinical TrialAcute and long-term outcome of transvenous cryothermal catheter ablation of supraventricular arrhythmias involving the perinodal region.
Cryoenergy is a new valuable treatment option to perform ablation close to the atrioventricular (AV) node in the cure of supraventricular tachycardias because of its favourable properties, such as the possibility of creating reversible lesions. The aim of this study was to report our experience on the effectiveness and safety of catheter cryoablation performed in "critical areas" to treat a large cohort of patients with supraventricular arrhythmias. ⋯ Cryoablation is a safe and effective technique with a high success rate in the long term. It may be particularly useful when performing ablation close to the AV node or His bundle owing to the possibility of validating the ablation site with ice mapping, which creates only a reversible lesion, mainly in the midseptal APs.