Journal of cardiovascular medicine
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J Cardiovasc Med (Hagerstown) · Aug 2009
Ischemia and reperfusion-induced arrhythmias: role of hyperoxic preconditioning.
Hyperoxic preconditioning is known to protect the heart against necrosis and contractile dysfunction, but protection against arrhythmias has not been well characterized. ⋯ These results indicate that hyperoxic preconditioning attenuates ventricular ischemia and reperfusion-induced arrhythmias in isolated rat hearts, decreases cardiac infarct size, and improves postischemic heart function. The effects seem to depend on the time course after hyperoxia treatment.