Acta physiologica

The most recent articles from: Acta Physiol (Oxf) November 2009

Acta physiologica · Nov 2009

Post-ischaemic activation of kinases in the pre-conditioning-like cardioprotective effect of the platelet-activating factor.

Platelet-activating factor (PAF) triggers cardiac pre-conditioning against ischemia/reperfusion injury. The actual protection of ischaemic pre-conditioning occurs in the reperfusion phase. Therefore, we studied in this phase the kinases involved in PAF-induced pre-conditioning. ⋯ The cardioprotective effect exerted by PAF pre-treatment involves activation of PKC and PI3K in post-ischaemic phases and might be mediated by the prevention of mPTP opening in reperfusion via GSK-3beta inactivation.

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