Acta physiologica
-
Administration of 100% oxygen [hyperoxic ventilation (HV)] has been proven to ameliorate oxygen transport, tissue oxygenation and survival in different models of extreme normovolemic and hypovolemic anaemia. However, up to date, it is unknown whether HV is also able to improve outcome of extreme anaemia if myocardial oxygen consumption is contemporaneously increased by tachycardia. Therefore, we investigated the influence of HV on the 6-h survival rate during extreme anaemia and aggravated by experimentally induced tachycardia in a prospective, randomized study in a pig model of critical anaemia. ⋯ Hyperoxic ventilation can be considered a safe and effective measure for the optimization of oxygen supply during extreme anaemia and despite concomitant tachycardia within 6 h. Whether HV can also be recommended beyond this period warrants further studies.