Equine veterinary journal
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Equine veterinary journal · Nov 2009
Controlled Clinical TrialPulmonary gas exchange in anaesthetised horses mechanically ventilated with oxygen or a helium/oxygen mixture.
It is unknown whether administration of gas-mixtures high in inspired fraction of oxygen (FiO2) under general anaesthesia may increase formation of pulmonary atelectasis and impair gas exchange. ⋯ Administration of a He/O2 gas mixture low in FiO2 can better preserve lung function than ventilation with pure oxygen. A step-wise increase of FiO2 using a He/O2 gas mixture might offer advantages with respect to pulmonary gas exchange over an immediate exposure to 100% 2O2.
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Equine veterinary journal · Nov 2009
Clinical TrialPlasma concentrations, behavioural and physiological effects following intravenous and intramuscular detomidine in horses.
Detomidine hydrochloride is used to provide sedation, muscle relaxation and analgesia in horses, but a lack of information pertaining to plasma concentration has limited the ability to correlate drug concentration with effect. ⋯ Results support a significant influence of route of administration on desirable and undesirable drug effects that influence case management.