Giornale italiano di cardiologia : organo ufficiale della Federazione italiana di cardiologia : organo ufficiale della Società italiana di chirurgia cardiaca
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G Ital Cardiol (Rome) · May 2015
Randomized Controlled Trial Multicenter Study[The POISE-2 Clonidine trial].
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G Ital Cardiol (Rome) · May 2015
Randomized Controlled Trial Multicenter Study[The POISE-2 Aspirin trial].
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G Ital Cardiol (Rome) · Apr 2015
Review[Metformin and left ventricular remodeling after acute myocardial infarction: molecular mechanisms and clinical implications].
Despite clear advances in reperfusion therapy and pharmacological treatment, a large proportion of patients with an acute myocardial infarction will die of its consequences. In this regard, it is very important to understand the molecular processes underpinning ischemia-reperfusion injury and occurrence of left ventricular dysfunction, with the aim to develop mechanism-based therapeutic strategies. Experimental evidence indicates that metformin, a biguanide often used in the treatment of diabetes, has favorable effects on left ventricular function. ⋯ Based on these results, it remains unclear whether metformin exerts a cardioprotective effect regardless of glycemic control. Further randomized studies in diabetic and nondiabetic patients are required to address these important questions. The present review critically discusses established knowledge and evidence gaps on the effects of metformin on left ventricular function in diabetic and nondiabetic patients with myocardial infarction.
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G Ital Cardiol (Rome) · Apr 2015
Case Reports[Interrupted aortic arch in a 68-year-old female with hypertension].
Interrupted aortic arch (IAA) is a rare congenital malformation of the aorta and aortic arch. We report the case of a 68-year-old female with hypertension and poor control of blood pressure levels. She was diagnosed with aortic coarctation by aortography during young age. A double access angiography was performed that showed a type A IAA, a rare condition in adults that may cause hypertension.