Internal and emergency medicine
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Gallstones are among the most frequent hepatobiliary conditions. Although in most cases, they remain asymptomatic, they can cause complications and, in such cases, invasive treatments like endoscopic retrograde cholangiography (ERC) or cholecystectomy are required. Here, we present the results of genetic testing of a single family with a high incidence of symptomatic gallstones and cholestatic liver phenotypes. ⋯ All genotyped patients also carried the predisposing variants c.1331C>T and c.3084A>G of the hepatobiliary bile salt export pump ABCB11 in either heterozygous or homozygous form. Hence, we propose that these variants taken together may have contributed to the high frequency of gallstone disease in this family, although functional studies for some variants are still lacking. In this report, we present these findings and discuss the challenges associated with interpreting sequencing data.
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Dream is a mental activity that occurs during sleep. Its interpretation is common practice in many African cultures and this role is vested in unqualified persons, such as diviners, priests, and healers. ⋯ This review manuscript unraveled the enigma of dreams by delving into the mechanisms underlying their occurrence, exploring the brain processes that shape their content, discussing different types of dreams, and examining the potential scientific basis for interpreting their significance. The scientific study of dreams and their interpretation has provided fascinating insights into the neural processes, cognitive functions, and emotional dimensions of this intriguing phenomenon.
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Identifying frequent users of Emergency Medical Services (EMS) in the post-discharge period can potentially direct interventions to prevent deterioration at home. This study aimed to describe the frequency of post-discharge emergency phone calls within 30 days after common medical and surgical categories of hospital admission. A retrospective cohort study retrieved data from the electronic medical record and the EMS Capital Region Denmark database after approval by the Danish Health Data Authority. ⋯ Patients discharged after medical hospitalization due to AECOPD contacted EMS 15 (95% CI: 13-16) times per 1000 patient days only surpassed by sepsis with 19 calls per 1000 patient days (95% CI: 17-21). Patients undergoing colorectal surgery had an EMS call frequency of 7.5 (95% CI: 6.4-8.7) and highest among types of surgery was hip- and knee replacements with 12 (95% CI: 11-13) calls per 1000 patient days. Patients discharged after hospitalization due to AECOPD and sepsis had a higher 30-day EMS call frequency compared with other medical cohorts, whereas major orthopedic surgery was followed by more EMS calls than admissions for colorectal surgery.