Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES
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Ulus Travma Acil Cerrahi Derg · Jan 2025
Effects of Rosmarinus officinalis extract on wound healing, colon anastomosis, and postoperative adhesion in colon anastomosis rats.
Intraabdominal adhesions increase the incidence and length of surgical complications. Many anti-adhesive agents have been used for this purpose, but no definitive solution has yet been found. Studies on the prevention and reduction of anastomotic leakage, therefore, remain up to date. This study aimed to determine the effects of Rosmarinus Officinalis extract on colon anastomosis as a surgical model, its antiadhesive activity, and its impact on wound healing in the laparotomy site simultaneously to facilitate the clinical application of Rosmarinus Officinalis extract. ⋯ According to the findings of our investigation, peritoneal administration of Rosmarinus Officinalis extract in the early postoperative period may increase the risk of evisceration in the abdominal incision site.
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Ulus Travma Acil Cerrahi Derg · Jan 2025
The effect of carvacrol on reducing bacterial translocation, liver and intestinal damage in obstructive jaundice models of rats.
BACKGROUND Obstructive jaundice is a common surgical issue caused by obstruction in the bile ducts, which can result from factors such as stones or cancers in the main bile duct. This study aimed to investigate the effects of carvacrol, a compound known for its strong antioxidant properties, on intestinal damage, liver damage, and bacterial translocation in an animal model of obstructive jaundice. METHODS The study utilized six groups of six Wistar Albino rats each. ⋯ Despite carvacrol's known antioxidant properties, it failed to show benefits in this experimental model. CONCLUSION Carvacrol, while recognized for its antioxidant effects, did not demonstrate therapeutic efficacy in treating obstructive jaundice in rats. The study suggests that further research with a larger sample size may be necessary to potentially uncover positive effects and better understand carvacrol's potential role in managing obstructive jaundice.