Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
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Review
The CXCR4/SDF-1 chemokine receptor axis: a new target therapeutic for non-small cell lung cancer.
Chemokines are proinflammatory chemoattractant cytokines that regulate cell trafficking and adhesion. The CXCR4 chemokine receptor and its ligand, stromal cell derived factor (SDF-1), constitute a chemokine/receptor axis that has attracted great interest because of an increasing understanding of its role in cancer, including lung cancer. ⋯ Neutralization of SDF-1 by anti-SDF-1 or anti-CXCR4 monoclonal antibody in preclinical in vivo studies results in a significant decrease of non-small cell lung cancer metastases. Since anti-SDF-1/CXCR4 strategies have already been developed for use in combating human immunodeficiency virus infections, it is likely that these approaches will be used in clinical trials in non-small cell lung cancer in the very near future.
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Multicenter Study
Efficacy and safety of erlotinib monotherapy for Japanese patients with advanced non-small cell lung cancer: a phase II study.
The aim of this study was to evaluate the efficacy and safety of Erlotinib in Japanese patients with previously treated non-small cell lung cancer (NSCLC). Available tumor biopsy samples were analyzed to examine relationships between biomarkers and clinical outcome. ⋯ Erlotinib is efficacious in Japanese patients with previously treated NSCLC. The toxicity profile was similar to that in Western patients, except for a somewhat higher incidence of skin disorders and interstitial lung disease. Further studies are needed to determine the relationship between epidermal growth factor receptor mutations and outcomes with Erlotinib in Japanese patients.
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Comparative Study
Use of Maximum Intensity Projections (MIPs) for target outlining in 4DCT radiotherapy planning.
Four-dimensional computed tomography (4DCT) is currently being introduced to radiotherapy centers worldwide, for use in radical radiotherapy planning for non-small cell lung cancer (NSCLC). A significant drawback is the time required to delineate 10 individual CT scans for each patient. Every department will hence ask the question if the single Maximum Intensity Projection (MIP) scan can be used as an alternative. Although the problems regarding the use of the MIP in node-positive disease have been discussed in the literature, a comprehensive study assessing its use has not been published. We compared an internal target volume (ITV) created using the MIP to an ITV created from the composite volume of 10 clinical target volumes (CTVs) delineated on the 10 phases of the 4DCT. ⋯ To prevent under-treatment of disease, the MIP image can only be used for delineation in Stage I tumors.