Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
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Tumor spread through air spaces (STAS) has recently been reported as a form of tumor invasion having an unfavorable prognosis, but the significance of a small amount of STAS is not known. The aim of this study was to perform a semiquantitative assessment of STAS. ⋯ We found that one-third of resected small adenocarcinomas had high STAS. Higher STAS was predictive of worse RFS.