Expert review of clinical pharmacology
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Expert Rev Clin Pharmacol · Jan 2014
CommentCanagliflozin versus glimepiride treatment in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU trial).
Evaluation of: Cefalu WT, Leiter LA, Yoon KH et al. Efficacy and safety of canagliflozin versus glimepiride in patients with Type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52-week results from a randomized, double-blind, Phase III non-inferiority trial. Lancet 382, 941-950 (2013). ⋯ Blood pressure was modestly reduced by both CANA treatments. Both high-density lipoprotein and low-density lipoprotein cholesterol were increased by both doses of CANA compared to glimepiride. Documented hypoglycemia was lower with CANA, but polyuria, pollakiuria, genital mycotic and urinary tract infections were significantly greater in both doses of CANA compared to glimepiride.