Expert review of clinical pharmacology
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Expert Rev Clin Pharmacol · Apr 2017
ReviewCannabinoids therapeutic use: what is our current understanding following the introduction of THC, THC:CBD oromucosal spray and others?
The complexity of the endocannabinoid (eCB) system is becoming better understood and new drivers of eCB signaling are emerging. Modulation of the activities of the eCB system can be therapeutic in a number of diseases. Research into the eCB system has been paralleled by the development of agents that interact with cannabinoid receptors. ⋯ Clinical trials have confirmed its efficacy and tolerability. Other diseases in which different cannabinoids are currently being investigated include various pain states, Alzheimer's disease, Parkinson's disease, Huntington's disease and epilepsy. The continued characterization of individual cannabinoids in different diseases remains important.
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Expert Rev Clin Pharmacol · Apr 2017
Meta AnalysisCollaborative approach of individual participant data of prospective studies of de-escalation in non-immunosuppressed critically ill patients with sepsis.
There is a concern to conduct de-escalation in very sick patients. ⋯ In our study there was an independent association of de-escalation and decrease mortality rate.