Expert review of clinical pharmacology
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Expert Rev Clin Pharmacol · Aug 2021
Obesity decreases the EC50 of epidural ropivacaine when combined with dexmedetomidine for labor analgesia.
This study aims to estimate the EC50 of ropivacaine when co-administered with dexmedetomidine for epidural labor analgesia in antepartum obese and non-obese parturients. ⋯ Patients with antepartum obese may require decreased ropivacaine concentration for epidural labor analgesia when co-administered with 0.5 µg/mL dexmedetomidine.