Reproductive sciences
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Reproductive sciences · Jan 2010
The effect of oxytocin and an oxytocin antagonist on the human myometrial proteome.
The immediate effects of oxytocin on myometrial signal transduction have been described. However, the longer term effects (up to an hour) on the myometrial proteome have not. We combined in vitro contractility with proteomic analysis to determine the protein changes associated with oxytocin-induced myometrial activity. ⋯ This study demonstrates that oxytocin has longer term (1 hour) effects on the myometrial proteome.