Expert opinion on drug discovery
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Expert Opin Drug Discov · Dec 2009
A review of in vitro and in vivo models of oesophageal and gastric cancer.
Oesophageal and gastric cancers are leading causes of cancer-related mortality. In the era of targeted therapy and individualized treatment strategies, novel treatments for upper-gastrointestinal cancers are only just emerging compared to significant advances in other solid tumour types such as colorectal, breast and lung cancers. Clinical trials are investigating the value of established targeted agents for the treatment of oesophageal and gastric malignancies; however none are used in routine clinical practice. ⋯ The lack of appropriate models for drug development in oesophageal and gastric cancers has hindered the progress of targeted therapy in this field.