Current opinion in supportive and palliative care
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Curr Opin Support Palliat Care · Mar 2010
ReviewRole of cervical cordotomy and other neurolytic procedures in thoracic cancer pain.
Evaluation of the efficacy and safety of the percutaneous cervical cordotomy (PCC) in palliative care medicine in patients suffering from thoracic cancer pain; fluoroscopy-guided versus computed tomographic-guided PCC. Evaluation of recent developments in other neurolytic procedures in thoracic pain. ⋯ The results of fluoroscopy-guided PCC are satisfactory with case series reporting complete pain reduction in as much as 82-95% of the patients. For CT-guided PCC initial success rates were reported between 80.5-92.5% patients. However, the complication rates and long-term effects if measured and/or mentioned, varied. Hypothetically this technique may be more accurate and therefore probably safer than fluoroscopic-guided PCC.
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Opioids are invaluable in the treatment of moderate-to-severe pain. Unfortunately, their prolonged use may be associated with the onset of opioid-induced hyperalgesia (OIH). This review focuses on recent clinical studies that support or refute the existence of OIH in patients. ⋯ Improvements in paradoxical pain intensity upon discontinuation of opioid therapy suggests that a multidisciplinary method of pain relief is favoured for chronic-pain patients. Quantitative-sensory testing of pain is offered as the most appropriate way of diagnosing hyperalgesia. We can, thus far only reliably validate the existence of OIH development in normal human volunteers receiving acute-morphine infusions.