Current opinion in supportive and palliative care
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Curr Opin Support Palliat Care · Jun 2019
ReviewAssessment of conditioned pain modulation in healthy participants and patients with chronic pain: manifestations and implications for pain progression.
The purpose of this review is to summarize recent findings on conditioned pain modulation (CPM) in humans with a focus on methodology, factors modulating CPM, and the potential for CPM as a clinical marker for pain progression. ⋯ As CPM methodology is optimized, studies are revealing factors that can modulate descending pain inhibitory pathways. Understanding underlying mechanisms of CPM will improve the utility of CPM in a clinical setting and potentially lead to personalized treatments for chronic pain patients.