Brain and nerve = Shinkei kenkyū no shinpo
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The failure of axonal regeneration after central nervous system (CNS) injury is thought to be due in part to the expression of molecules inhibitory for axonal growth and/or the lack of neurotrophic factors. Antibody treatment to neutralize axon growth inhibitory activity, and delivery of neurotrophic factor have been attempted extensively to overcome inhibition and augment regeneration of spinal motor pathways. Local delivery of neurotrophins can counteract pathological events and induce a regenerative response after both acute and chronic spinal cord injury. ⋯ The locomotor function of the FGF-2-treated animals was substantially recovered up to extent where the joint of the hind limb moves 6 weeks after transection, but the recovery was not seen at all on the locomotor activity of the vehicle-treated animals. This regeneration might be facilitated by prominant cell growth of fibroblast-like cells markedly enhanced by FGF-2 around the lesion site, because the cells have properties advantageous for neurite outgrowth. FGF-2-induced cells may become a crucial and promising tool to attain successful axonal regeneration.
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We reported the case of a 77-year-old female who presented with left hypoglossal paresis and dysarthria due to a small cortical infarction. She was admitted to our hospital because of the sudden onset of dysarthria. A neurological examination revealed deviation of the tongue to the left and paretic dysarthria without motor paralysis in the extremities. ⋯ Furthermore, in this patient, dysarthria in this case was more obvious than that of peripheral hypoglossal palsy. Recent electrophysiological has investigation indicates that the corticolingual tract plays a significant role in the presence of pure dysarthria in the stroke patients. This case indicate that cortical infarction in the primary motor cortex may produce isolated hypoglossal nerve paresis and dysarthria due to disruption of the corticolingual tract.