Brain and nerve = Shinkei kenkyū no shinpo
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Microtubules are key cytoskeletal elements found in all eukaryotic cells. Tau was identified as microtubule associated protein and was implicated in microtubule initiation as well as assembly. Its expression is increased expression in neurons and has a specific association with axonal microtubules. ⋯ In PSP NFTs, tufted astrocytes, coiled bodies and threads contain 4R-tau and in CBD, pretangles, astrocytic plaques, coiled bodies and threads also demonstrate 4R-tau. Argyrophilic grains are immunopositive for 4R-tau. Although PSP and CBD sometimes share certain pathological distribution, which makes clinical diagnosis difficult, cellular tau pathology and aggregation patterns in neurons and glia are different between the two diseases.