Brain and nerve = Shinkei kenkyū no shinpo
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Review Case Reports
[The contribution of patient H.M. to modern neuroscience].
In 1953, 27-year-old H. M. underwent bilateral medial temporal lobes resection to control his seizures; however, he suffered from severe amnesia as a result. For the next five decades until his death in December 2008 at the age 82, he was the subject of numerous studies performed by over 100 investigators. ⋯ M. study encouraged the concept of medial temporal lobe memory system and multiple memory systems, and suggested the slow acquisition of semantic knowledge without medial temporal lobe memory system through repeated experience. By the grace of H. M.'s lifelong contribution, the neuroscience of memory is in full flourish.