Medicina
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Case Reports
[Failure of the treatment with penicillin in a case of Neisseria meningitidis meningitis].
Most Neisseria meningitidis are susceptible to penicillin with a minimal inhibitory concentration (MIC) < or = 0.6 mg/L and mortality related to meningococcal meningitis has been low. In recent years, however, N. meningitidis moderately susceptible to penicillin (MIC 0.12-1 mg/L) has been isolated in South Africa, England, USA, and mainly Spain. We report a case of a 16-year old male patient, who was admitted with a diagnosis of meningitis. ⋯ A third lumbar puncture performed on the eighth day after admission showed a negative bacteriological culture. The patient was discharged without neurological sequelae after 14 days of treatment. This case report shows that small changes in N. meningitidis sensitivity may be of clinical relevance.