Current opinion in endocrinology, diabetes, and obesity
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Curr Opin Endocrinol Diabetes Obes · Dec 2008
ReviewAssisted reproduction and fertility preservation techniques in cancer patients.
This study aims to review the current state of different fertility preservation options in patients facing the risk of gonadal failure. ⋯ Embryo cryopreservation is a well established technique to preserve fertility. The success rate with oocyte cryopreservation has been on the rise. Both oocyte and embryo freezing require ovarian stimulation and novel ovarian stimulation regimens utilizing aromatase inhibitors which have been developed for ovarian stimulation in women with estrogen sensitive cancer. Even though ovarian tissue cryopreservation is a novel technology, it is the only fertility preservation option for children and the only treatment strategy that can restore ovarian function. In-vitro maturation is a promising technology and can be applied in combination with ovarian tissue cryopreservation.