Therapeutic advances in respiratory disease
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Ther Adv Respir Dis · Feb 2017
ReviewThe evolving landscape of combination therapy for pulmonary arterial hypertension.
Pulmonary arterial hypertension (PAH) is a progressively fatal disease, and the goal in treatment is to prevent disease progression. The standard of care often involves medications from multiple therapeutic classes, and there has been significant interest both in the choice of agent as well as the timing of initiation. There is a growing body of support for starting multiple medications at the time of diagnosis, or 'upfront ', rather than using sequential addition to prevent clinical deterioration.