Journal of Crohn's & colitis
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Treatment of complex perianal fistulas associated with Crohn's disease is challenging. In adults, seton drainage combined with infliximab therapy has proven to be more effective than either one alone. Results following such treatment among pediatric patients have not been reported previously. The aim of this study was to describe outcomes after combined seton and infliximab treatment for complex perianal fistulas in adolescents with Crohn's disease. ⋯ The results suggest that combining seton drainage with infliximab therapy improves the perianal fistula response rates in pediatric patients.