Cardiovascular therapeutics
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Randomized Controlled Trial Comparative Study
Effects of beta-blockade on exercise performance at high altitude: a randomized, placebo-controlled trial comparing the efficacy of nebivolol versus carvedilol in healthy subjects.
Exposure to high altitude (HA) hypoxia decreases exercise performance in healthy subjects. Although β-blockers are known to affect exercise capacity in normoxia, no data are available comparing selective and nonselective β-adrenergic blockade on exercise performance in healthy subjects acutely exposed to HA hypoxia. We compared the impact of nebivolol and carvedilol on exercise capacity in healthy subjects acutely exposed to HA hypobaric hypoxia. ⋯ Exercise performance is better preserved with nebivolol than with carvedilol under acute exposure to HA hypoxia in healthy subjects.
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Aspirin resistance may be linked to increased risk of cardiovascular events. We aimed to evaluate whether it was associated with presence of microembolic signals (MES), a readily measurable marker of increased stroke risk, in those with internal carotid artery (ICA) disease. ⋯ Aspirin resistance appears more common in patients with carotid disease who have MES compared to those without. Further work should aim to establish whether screening for aspirin resistance and subsequent adjustment to antiplatelet therapy reduces the rate of MES and stroke risk in those with carotid disease.