The American journal of cardiology
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Multicenter Study Clinical Trial
Factors influencing the time to administration of thrombolytic therapy with recombinant tissue plasminogen activator (data from the National Registry of Myocardial Infarction). Participants in the National Registry of Myocardial Infarction.
Very early administration of thrombolytic therapy for acute myocardial infarction (AMI) has significantly reduced mortality in eligible patients. The purpose of this study was to evaluate factors which influenced the time from symptom onset to hospital presentation and the time from hospital presentation to the onset of thrombolytic treatment in a large population of patients with AMI. This study included 212,990 patients from 904 hospitals that participated in the National Registry of Myocardial Infarction. ⋯ The most important factor associated with shorter time to treatment was the initiation of thrombolytic treatment in the emergency department rather than in the coronary care unit (47 vs 73 minutes, p < 0.0001). Hospital treatment times are much too long, given that quick identification and treatment of eligible patients are of primary importance in reducing mortality from AMI. To shorten these times, thrombolytic treatment should be initiated in the emergency department, and the effectiveness of hospital programs aimed at reducing time to treatment should be subject to continuing quality improvement surveillance.
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Anatomic indexes of the LAA are dependent on the plane in which the appendage is viewed. Greater LAA neck width and cross-sectional area are observed at 135 degrees than at 45 degrees or 90 degrees, consistent with the characteristic 3-dimensional ungular shape of this structure. Appendage ejection and inflow velocity measurements are independent of the imaging plane.
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Signal-averaged electrocardiography and 24-hour ambulatory electrocardiographic monitoring were performed in 121 elderly patients > 6 months after acute myocardial infarction. All patients had asymptomatic complex ventricular arrhythmias and a left ventricular ejection fraction > or = 40%. Rates of sudden, cardiac, and total death were compared between groups with and without nonsustained ventricular tachycardia and between normal and abnormal signal-averaged electrocardiographic studies. ⋯ The negative predictive value of having neither an abnormal signal-averaged electrocardiogram nor nonsustained ventricular tachycardia was 94% for sudden death. In elderly patients with complex ventricular arrhythmias and ejection fraction > or = 40% at least 6 months after an acute myocardial infarction, presence of nonsustained ventricular tachycardia predicted a higher rate of sudden and cardiac death. Signal-averaged electrocardiography alone was not predictive.