The American journal of cardiology
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Review Meta Analysis
Meta-Analysis Comparing Results of Transcatheter Versus Surgical Aortic-Valve Replacement in Patients With Severe Aortic Stenosis.
Transcatheter aortic-valve replacement (TAVR) has emerged as a promising strategy for treating patients with severe aortic stenosis. We aimed to compare TAVR with surgical aortic-valve replacement (SAVR) and determine the performance of TAVR over time and within several subgroups. We included 8 randomized trials comparing TAVR versus SAVR. ⋯ TAVR with transfemoral approach and new-generation valve was associated with reduction in all-cause mortality or disabling stroke compared with corresponding comparators. In conclusion, TAVR was associated with a lower risk for all-cause mortality or disabling stroke within 2 years, but not at long-term follow-up compared with SAVR; the risks seems to increase over time. More data are needed to determine longer-term performance of TAVR.
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Review Meta Analysis
Meta-Analysis of Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement in Patients With Low Surgical Risk.
Transcatheter aortic valve implantation (TAVI) is the current standard of care for patients with severe aortic stenosis who are at high risk for surgery. However, several recent studies have demonstrated the comparable safety and efficacy of TAVI in low-risk patients as well. We sought to pool the existing data to further assert its comparability. ⋯ Subgroup analysis of randomized controlled trials showed significantly lower 1-year all-cause mortality in the TAVI group. In conclusion, in severe aortic stenosis patients at low surgical risk, TAVI when compared with surgical aortic valve replacement, demonstrated a lower rate of short-term all-cause mortality, short-term, and 1-year cardiac mortality and similar in terms of 1-year all-cause mortality. TAVI is emerging as a safe and efficacious alternative for low surgical risk patients.
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Observational Study
Impact of Sex on Survival and Neurologic Outcomes in Adults With In-Hospital Cardiac Arrest.
Data regarding the impact of sex on clinical outcomes in adults with in-hospital cardiac arrest (IHCA) have yielded conflicting results. We aimed to study the impact of female sex on mortality and poor neurologic outcomes in adults with IHCA. The study population included 680 consecutive patients hospitalized with IHCA who underwent ACLS-guided resuscitation from 2012 to 2018 at an academic tertiary medical center. ⋯ With respect to outcomes, women were noted to have significantly higher rates of in-hospital mortality (87.5% vs 78.0%; p = 0.001) and lower rates of favorable neurologic outcome (10.0% vs 15.8%, p = 0.030) compared with men. In multivariable analyses, female sex was independently associated with nearly two-fold higher rates of in-hospital mortality [odds ratio (OR) 1.93, 95% confidence interval (CI) 1.22-3.04, p = 0.005] and a trend toward lower rates of favorable neurologic outcome (OR 0.63, 95% CI 0.38-1.04, p = 0.071). In conclusion, in this prospective, contemporary registry of adults with IHCA, female sex was independently associated with nearly twofold higher rates of in-hospital mortality and a trend toward lower rates of favorable neurologic outcomes.