CNS neuroscience & therapeutics
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Severe traumatic brain injury (TBI) results in long-term neurological deficits associated with white matter injury (WMI). Ethyl pyruvate (EP) is a simple derivative of the endogenous energy substrate pyruvate with neuroprotective properties, but its role in recovery from WMI has not been explored. ⋯ EP treatment may protect TBI-induced WMI via modulating microglia polarization toward M2.