Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
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Neuropsychopharmacology · Oct 2005
Clinical TrialPsychopathology in the offspring of parents with bipolar disorder: a controlled study.
To examine the risk for psychopathology in offspring at risk for bipolar disorder and the course of psychiatric disorders in these youth. ⋯ These findings support the hypothesis that offspring of parents with bipolar disorder are at significantly increased risk for developing a wide range of severe psychiatric disorders and accompanying dysfunction. Early disruptive behavior and anxiety disorders, as well as early-onset depression, may be useful markers of risk for subsequent bipolar disorder in high-risk samples.