Circulation. Arrhythmia and electrophysiology
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Circ Arrhythm Electrophysiol · Oct 2014
Randomized Controlled Trial Multicenter StudyMortality reduction in relation to implantable cardioverter defibrillator programming in the Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT).
The benefit of novel implantable cardioverter defibrillator (ICD) programming in reducing inappropriate ICD therapy and mortality was demonstrated in Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT). However, the cause of mortality reduction remains incompletely evaluated. We aimed to identify factors associated with mortality, with focus on ICD therapy and programming in the MADIT-RIT population. ⋯ clinicaltrials.gov Unique identifier: NCT00947310.
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Circ Arrhythm Electrophysiol · Oct 2014
Multicenter StudyCardiac evaluation of pediatric relatives in sudden arrhythmic death syndrome: a 2-center experience.
Sudden arrhythmic death syndrome defines a sudden unexpected and unexplained death despite comprehensive pathological and toxicological investigation. Previous studies have focused on evaluation of adult relatives. There is, however, a lack of data in children, leading to highly variable management. We sought to determine the clinical utility of cardiac evaluation in pediatric relatives of sudden arrhythmic death syndrome probands. ⋯ The yield of evaluating pediatric relatives is significant and higher when focused on first-degree relatives and on conditions usually expressed in childhood. We propose a management pathway for these children.
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Circ Arrhythm Electrophysiol · Oct 2014
Observational StudySurvival after primary prevention implantable cardioverter-defibrillator placement among patients with chronic kidney disease.
Guidelines recommend that implantable cardioverter-defibrillator (ICD) candidates have an estimated longevity of ≥1 year. Longevity can be affected by chronic kidney disease (CKD). ⋯ The risk of death after primary prevention ICD placement is proportional to CKD severity. Among patients with CKD, several factors are prognostically significant and could inform clinical decision making on primary prevention ICD candidacy.