International journal of rheumatic diseases
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To validate the Oxford Knee Score (OKS) in outpatients with knee osteoarthritis (OA). ⋯ The OKS has demonstrated good psychometric properties and thus can be considered a reliable and valid measurement for outpatients with OA.
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Osteoarthritis is a leading cause of disability with incidence and prevalence rising in most nations. Management to address the degenerative joint is stratified according to degree of severity of involvement and always begins with non-surgical modalities before progressing through a range of surgeries, including arthroscopy, osteotomy, unicompartmental and total knee replacement. ⋯ Complications, poor patient satisfaction and joint function can be directly attributable to obesity. Efforts to address obesity should be considered as part of the approach to managing osteoarthritis.
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Fibromyalgia syndrome (FMS) is a chronic disorder of widespread pain with high personal and societal burdens. Although targeted pharmacotherapies have become available in recent years, it remains a challenging condition to treat. Despite no randomized controlled trials addressing the short- or long-term use of opioids in FMS, their use remains prevalent. ⋯ Finally, we discuss drugs with combined opioid and anti-opioid action and their roles in FMS. There is insufficient evidence to recommend the routine use of opioids in FMS. As well as having a significant adverse effect profile, their inefficacy may be due to their inability to target the pathophysiologic processes involved in this central sensitization syndrome.
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Clinical Trial
Leflunomide in Pakistani patients with rheumatoid arthritis: prospective study in daily rheumatology practice.
Leflunomide is a disease-modifying anti-rheumatic drug (DMARD) for rheumatoid arthritis (RA). It has been widely studied in the West but there is no available local Pakistani data. ⋯ This prospective study conducted in the setting of a daily rheumatology practice shows that leflunomide is an effective and safe DMARD in treatment of RA in Pakistani patients.
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To investigate the clinical characteristics of patients with Churg-Strauss syndrome (CSS), including symptoms, blood chemistry and immunological findings. ⋯ Although general assessments based on various factors such as medical history, clinical manifestation and laboratory studies are indispensable in CSS, MPO-ANCA might be useful as a predictor of renal dysfunction in patients with CSS.