International journal of rheumatic diseases
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Randomized Controlled Trial
Application of a real-time pain monitoring system in Korean fibromyalgia patients: A pilot study.
Chronic pain is a debilitating condition which should be managed with integrated multidisciplinary approaches. To this end, accurate pain assessment should be the first step, and self-reporting pain assessment systems using smartphones or wearable devices are being introduced. The aim of the study was to evaluate the utility and efficacy of a real-time pain monitoring system using a wearable device, referred to as the Pain Assessment and Analysis System (PAAS), in patients with fibromyalgia, which is characterized by widespread chronic pain. ⋯ The proposed real-time pain monitoring system can be utilized for pain assessment in Korean fibromyalgia patients. Moreover, the system accurately reflects pain status and may help to alleviate pain.
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Randomized Controlled Trial Comparative Study
Which one is more effective for the clinical treatment of chronic pain in knee osteoarthritis: radiofrequency neurotomy of the genicular nerves or intra-articular injection?
To compare the efficacy of intra-articular injection and radiofrequency (RF) neurotomy of genicular nerves in patients with chronic knee osteoarthritis (OA) pain. ⋯ This study is the first controlled study in the literature which compares RF genicular nerve to intra-articular injections. This study demonstrated that genicular nerve RF neurotomy is a safe and efficient treatment modality and provides functional improvement along with an analgesia in patients with chronic knee OA.
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Randomized Controlled Trial Comparative Study
Clinical outcomes are associated with changes in ultrasonographic structural appearance after platelet-rich plasma treatment for knee osteoarthritis.
Hyaluronic acid (HA) and platelet-rich plasma (PRP) are two treatment options used for knee osteoarthritis (KOA) but studies comparing the efficacy of the two yield conflicting results. In addition, the association of clinical outcomes of PRP intra-articular injections with changes in the ultrasonography structural appearance of the knee has not been investigated. ⋯ Intra-articular injection of PRP is an effective treatment that reduced pain and improved functional status in patients with KOA. The clinical outcomes of the intra-articular injections of PRP are associated with improved synovial hypertrophy and vascularity scores, and less effusion.
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Randomized Controlled Trial Comparative Study
Tofacitinib with conventional synthetic disease-modifying antirheumatic drugs in Chinese patients with rheumatoid arthritis: Patient-reported outcomes from a Phase 3 randomized controlled trial.
Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We assess the effect of tofacitinib + conventional synthetic disease-modifying anti rheumatic drugs (csDMARDs) on patient-reported outcomes in Chinese patients with RA and inadequate response to DMARDs. ⋯ Tofacitinib 5 and 10 mg twice daily + csDMARDs resulted in improvements in health-related quality of life, physical function and Pain through 12 months in Chinese patients with RA.
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Randomized Controlled Trial Comparative Study
Local steroid injection versus wrist splinting for carpal tunnel syndrome: A randomized clinical trial.
We conducted a prospective randomized parallel clinical trial comparing the efficacy of local steroid injection and nocturnal wrist splinting in patients with carpal tunnel syndrome (CTS). ⋯ Although local steroid injection and nocturnal wrist splinting were equally effective in the treatment of patients with CTS, only the former improved objective hand function. Local steroid injection also resulted in better patient satisfaction and less painkiller use without causing more side effects.