Journal of aerosol medicine and pulmonary drug delivery
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J Aerosol Med Pulm Drug Deliv · Jun 2014
ReviewPediatric in vitro and in silico models of deposition via oral and nasal inhalation.
Respiratory tract deposition models provide a useful method for optimizing the design and administration of inhaled pharmaceutical aerosols, and can be useful for estimating exposure risks to inhaled particulate matter. As aerosol must first pass through the extrathoracic region prior to reaching the lungs, deposition in this region plays an important role in both cases. Compared to adults, much less extrathoracic deposition data are available with pediatric subjects. ⋯ Computational fluid dynamics simulations allow for the quantification of local deposition patterns and an in-depth examination of aerosol behavior in the respiratory tract. Recent studies have used both in vitro and in silico deposition measurements in realistic pediatric airway geometries to some success. This article reviews the current understanding of pediatric in vitro and in silico deposition modeling via oral and nasal inhalation.
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J Aerosol Med Pulm Drug Deliv · Jun 2014
Improved metered dose inhaler technique when a coordination cap is used.
Patients often experience problems using metered dose inhalers (MDIs), particularly poor coordination between inhalation start and dose actuation (TsIn: time difference between the start of an inhalation and the actuation of a dose), and fast peak inspiratory flow (PIF). We investigated if a coordination cap (CAP), with instruction to prolong inhalation, solved these problems. ⋯ The cap with its effect of increasing resistance to airflow combined with the instruction to prolong inhalation time significantly decreased the inhalation flow.
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J Aerosol Med Pulm Drug Deliv · Jun 2014
Hood nebulization: effects of head direction and breathing mode on particle inhalability and deposition in a 7-month-old infant model.
Aerosol drug delivery to infants is a strong function of their behavior. Infants can be active during medication administration, changing head position or breathing mode. The objective was to evaluate the influence of the head direction and breathing mode on the hood drug delivery in a 7-month-old girl airway model by using an approach that couples imaging with computational fluid dynamics (CFD). Three head directions, i.e., face up, face side, and sitting (face front), and two breathing modes, i.e., oronasal and nasal breathing, were studied. ⋯ The face-side position has less facial-ocular deposition than the face-up position, while still achieving similar lung delivery efficiency. Because aerosols deposited around the eyes may cause irritation to the eyes, the face-side position appears to be a better option than the face-up position for comfort and safety reasons.