Molecular medicine reports
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Reduced nicotinamide adenine dinucleotide phosphate [NAD(P)H] oxidase is an important source of superoxide (O2-) in human blood vessels. A critical component of this oxidase is the p22phox protein, which is encoded by the cytochrome b-245 α (CYBA) gene. Studies have suggested a possible association between polymorphisms of the CYBA gene and susceptibility to atherosclerosis in diabetes mellitus (DM). ⋯ In non-diabetic subjects, the average carotid IMT of the TC+TT group did not differ from that of the CC group (0.81±0.08 vs. 0.84±0.069 mm, P>0.05). There was a significant positive correlation between carotid IMT and blood glucose level and duration. Our findings demonstrate that the CC genotype of the p22 phox gene is a risk factor for the progression of atherosclerosis in diabetic patients.