Molecular medicine reports
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Long non‑coding RNAs (lncRNAs) have been implicated in the development and progression of cancer. However, the mechanisms of lncRNAs in hepatitis B virus (HBV) infection‑induced hepatocellular carcinoma (HCC) remain unclear. The study aimed to reveal the roles of lncRNAs for HBV‑HCC based on the hypothesis of competing endogenous RNA (ceRNA). ⋯ Function enrichment analysis revealed the genes in the ceRNA network that participated in the p53 signaling pathway [cyclin E2 (CCNE2), ribonucleotide reductase M2 subunit (RRM2)] and nitrogen metabolism [carbonic anhydrase 2 (CA2)], which were also included in the pathways of the CTD. Univariate Cox regression analysis revealed that six RNAs (2 DELs: FAM138B, SSTR5‑AS1; 2 DEMs: hsa‑miR‑149, hsa‑miR‑7; 2 DEGs: CCNE2, RRM2) were significantly associated with OS; while seven RNAs (1 DEL: LINC00284; 3 DEMs: hsa‑miR‑7, hsa‑miR‑15b, hsa‑miR‑30c‑2; and 3 DEGs: RRM2, CCNE2, CA2) were significantly associated with RFS. In conclusion, FAM138B‑hsa‑miR‑30c‑CCNE2/RRM2 and the SSTR5‑AS1‑hsa‑miR‑15b‑5p‑CA2 ceRNA axes may be important mechanisms for HBV‑related HCC.