Circulation. Cardiovascular imaging
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Circ Cardiovasc Imaging · Mar 2015
Multicenter StudyLack of association between epicardial fat volume and extent of coronary artery calcification, severity of coronary artery disease, or presence of myocardial perfusion abnormalities in a diverse, symptomatic patient population: results from the CORE320 multicenter study.
Epicardial fat may play a role in the pathogenesis of coronary artery disease (CAD). We explored the relationship of epicardial fat volume (EFV) with the presence and severity of CAD or myocardial perfusion abnormalities in a diverse, symptomatic patient population. ⋯ In a diverse population of symptomatic patients referred for invasive coronary angiography, we did not find associations of EFV with the presence and severity of CAD or with myocardial perfusion abnormalities. The clinical significance of quantifying EFV remains uncertain but may relate to the pathophysiology of acute coronary events rather than the presence of atherosclerotic disease.
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Circ Cardiovasc Imaging · Mar 2015
Multicenter Study Observational StudyUsefulness of global left ventricular longitudinal strain for risk stratification in low ejection fraction, low-gradient aortic stenosis: results from the multicenter True or Pseudo-Severe Aortic Stenosis study.
The objective of this study was to examine the impact of left ventricular (LV) global longitudinal strain (GLS) measured at rest and at dobutamine stress echocardiography on the outcome of patients with low LV ejection fraction and low-gradient aortic stenosis. ⋯ http://www.clinicaltrials.gov. Unique identifier: NCT01835028.
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Circ Cardiovasc Imaging · Mar 2015
Randomized Controlled Trial Multicenter StudyUse of coronary artery calcium scanning beyond coronary computed tomographic angiography in the emergency department evaluation for acute chest pain: the ROMICAT II trial.
Whether a coronary artery calcium (CAC) scan provides added value to coronary computed tomographic angiography (CCTA) in emergency department patients with acute chest pain remains unsettled. We sought to determine the value of CAC scan in patients with acute chest pain undergoing CCTA. ⋯ http://www.clinicaltrials.gov. Unique identifier: NCT01084239.
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Circ Cardiovasc Imaging · Mar 2015
Multicenter Study Comparative Study Pragmatic Clinical TrialDetection of significant coronary artery disease by noninvasive anatomical and functional imaging.
The choice of imaging techniques in patients with suspected coronary artery disease (CAD) varies between countries, regions, and hospitals. This prospective, multicenter, comparative effectiveness study was designed to assess the relative accuracy of commonly used imaging techniques for identifying patients with significant CAD. ⋯ http://www.clinicaltrials.gov. Unique identifier: NCT00979199.
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Circ Cardiovasc Imaging · Mar 2015
Comparative Study Observational StudyEarly resting myocardial computed tomography perfusion for the detection of acute coronary syndrome in patients with coronary artery disease.
Acute rest single-photon emission computed tomography-myocardial perfusion imaging (SPECT-MPI) has high predictive value for acute coronary syndrome (ACS) in emergency department patients. Prior studies have shown excellent agreement between rest/stress computed tomography perfusion (CTP) and SPECT-MPI, but the value of resting CTP (rCTP) in acute chest pain triage remains unclear. We sought to determine the diagnostic accuracy of early rCTP, incremental value beyond obstructive coronary artery disease (CAD; ≥50% stenosis), and compared early rCTP to late stress SPECT-MPI in patients with CAD presenting with suspicion of ACS to the emergency department. ⋯ http://www.clinicaltrials.gov. Unique identifier: NCT00990262.